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HAC stability in murine cells is influenced by nuclear localization and chromatin organization
BACKGROUND: Human artificial chromosomes (HAC) are small functional extrachromosomal elements, which segregate correctly during each cell division. In human cells, they are mitotically stable, however when the HAC are transferred to murine cells they show an increased and variable rate of loss. In s...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674426/ https://www.ncbi.nlm.nih.gov/pubmed/19267891 http://dx.doi.org/10.1186/1471-2121-10-18 |