Hyaluronan inhibits expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic chondrocytes

BACKGROUND: Intra-articular injection of hyaluronan (HA) has been suggested to have a disease-modifying effect in osteoarthritis, but little is known about the possible mechanisms. OBJECTIVE: To investigate the effects of HA species of different molecular mass, including 800 kDa (HA800) and 2700 kDa...

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Detalles Bibliográficos
Autores principales: Yatabe, T, Mochizuki, S, Takizawa, M, Chijiiwa, M, Okada, A, Kimura, T, Fujita, Y, Matsumoto, H, Toyama, Y, Okada, Y
Formato: Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2009
Materias:
Basic and Translational Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674548/
https://www.ncbi.nlm.nih.gov/pubmed/18662930
http://dx.doi.org/10.1136/ard.2007.086884

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674548/
https://www.ncbi.nlm.nih.gov/pubmed/18662930
http://dx.doi.org/10.1136/ard.2007.086884

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