In vivo (1)H-magnetic resonance spectroscopy can detect metabolic changes in APP/PS1 mice after donepezil treatment

BACKGROUND: Donepezil improves cognitive functions in AD patients. Effects on the brain metabolites N-acetyl-L-aspartate, choline and myo-inositol levels have been reported in clinical studies using this drug. The APP/PS1 mouse coexpresses the mutated forms of human β-amyloid precursor protein (APP)...

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Detalles Bibliográficos
Autores principales: Westman, Eric, Spenger, Christian, Öberg, Johanna, Reyer, Henry, Pahnke, Jens, Wahlund, Lars-Olof
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674598/
https://www.ncbi.nlm.nih.gov/pubmed/19351388
http://dx.doi.org/10.1186/1471-2202-10-33

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674598/
https://www.ncbi.nlm.nih.gov/pubmed/19351388
http://dx.doi.org/10.1186/1471-2202-10-33

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