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In vivo (1)H-magnetic resonance spectroscopy can detect metabolic changes in APP/PS1 mice after donepezil treatment

BACKGROUND: Donepezil improves cognitive functions in AD patients. Effects on the brain metabolites N-acetyl-L-aspartate, choline and myo-inositol levels have been reported in clinical studies using this drug. The APP/PS1 mouse coexpresses the mutated forms of human β-amyloid precursor protein (APP)...

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Detalles Bibliográficos
Autores principales:	Westman, Eric, Spenger, Christian, Öberg, Johanna, Reyer, Henry, Pahnke, Jens, Wahlund, Lars-Olof
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674598/ https://www.ncbi.nlm.nih.gov/pubmed/19351388 http://dx.doi.org/10.1186/1471-2202-10-33

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