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Functionality and the evolution of marginal stability in proteins: Inferences from lattice simulations

It has been known for some time that many proteins are marginally stable. This has inspired several explanations. Having noted that the functionality of many enzymes is correlated with subunit motion, flexibility, or general disorder, some have suggested that marginally stable proteins should have a...

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Detalles Bibliográficos
Autores principales: Williams, Paul D., Pollock, David D., Goldstein, Richard A.
Formato: Texto
Lenguaje:English
Publicado: Libertas Academica 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674661/
https://www.ncbi.nlm.nih.gov/pubmed/19455204