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Dysregulation of glucocorticoid metabolism in murine obesity: comparable effects of leptin resistance and deficiency
In obese humans, metabolism of glucocorticoids by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) and A-ring reduction (by 5α- and 5β-reductases) is dysregulated in a tissue specific manner. These changes have been recapitulated in leptin resistant obese Zucker rats but were not observed in high-...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioScientifica
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674682/ https://www.ncbi.nlm.nih.gov/pubmed/19223399 http://dx.doi.org/10.1677/JOE-09-0003 |