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Dysregulation of glucocorticoid metabolism in murine obesity: comparable effects of leptin resistance and deficiency

In obese humans, metabolism of glucocorticoids by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) and A-ring reduction (by 5α- and 5β-reductases) is dysregulated in a tissue specific manner. These changes have been recapitulated in leptin resistant obese Zucker rats but were not observed in high-...

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Detalles Bibliográficos
Autores principales:	Livingstone, Dawn E W, Grassick, Sarah L, Currie, Gillian L, Walker, Brian R, Andrew, Ruth
Formato:	Texto
Lenguaje:	English
Publicado:	BioScientifica 2009
Materias:	Regular papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674682/ https://www.ncbi.nlm.nih.gov/pubmed/19223399 http://dx.doi.org/10.1677/JOE-09-0003

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