T cell sensitivity to TGF-β is required for the effector function but not the generation of splenic CD8(+) regulatory T cells induced via the injection of antigen into the anterior chamber

The introduction of antigen into the anterior chamber (AC) of the eye induces the production of antigen-specific splenic CD8(+) regulatory T cells (AC-SPL cells) that suppress a delayed-type hypersensitivity (DTH) reaction in immunized mice. Because the generation of these regulatory T cells is also...

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Detalles Bibliográficos
Autores principales: Cone, Robert E., Chattopadhyay, Subhasis, Sharafieh, Roshanak, Lemire, Yen, O'Rourke, James, Flavell, Richard A., Clark, Robert B.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675031/
https://www.ncbi.nlm.nih.gov/pubmed/19325036
http://dx.doi.org/10.1093/intimm/dxp023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675031/
https://www.ncbi.nlm.nih.gov/pubmed/19325036
http://dx.doi.org/10.1093/intimm/dxp023

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