Proteoglycan interactions with Sonic Hedgehog specify mitogenic responses

Sonic Hedgehog (Shh) has dual roles in vertebrate development, as it promotes progenitor cell proliferation and induces tissue patterning. Here we show mitogenic and patterning functions of Shh can be uncoupled from one another. Using a genetic approach to selectively inhibit Shh-proteoglycan intera...

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Detalles Bibliográficos
Autores principales: Chan, Jennifer A., Balasubramanian, Srividya, Witt, Rochelle M., Nazemi, Kellie J., Choi, Yoojin, Pazyra-Murphy, Maria F., Walsh, Carolyn O., Thompson, Margaret, Segal, Rosalind A.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676236/
https://www.ncbi.nlm.nih.gov/pubmed/19287388
http://dx.doi.org/10.1038/nn.2287

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676236/
https://www.ncbi.nlm.nih.gov/pubmed/19287388
http://dx.doi.org/10.1038/nn.2287

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