Drug Discovery Using Chemical Systems Biology: Identification of the Protein-Ligand Binding Network To Explain the Side Effects of CETP Inhibitors

Systematic identification of protein-drug interaction networks is crucial to correlate complex modes of drug action to clinical indications. We introduce a novel computational strategy to identify protein-ligand binding profiles on a genome-wide scale and apply it to elucidating the molecular mechan...

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Detalles Bibliográficos
Autores principales: Xie, Li, Li, Jerry, Xie, Lei, Bourne, Philip E.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676506/
https://www.ncbi.nlm.nih.gov/pubmed/19436720
http://dx.doi.org/10.1371/journal.pcbi.1000387

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676506/
https://www.ncbi.nlm.nih.gov/pubmed/19436720
http://dx.doi.org/10.1371/journal.pcbi.1000387

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