Mitochondrial DNA Variants of Respiratory Complex I that Uniquely Characterize Haplogroup T2 Are Associated with Increased Risk of Age-Related Macular Degeneration

BACKGROUND: Age-related macular degeneration (AMD), a chronic neurodegenerative and neovascular retinal disease, is the leading cause of blindness in elderly people of western European origin. While structural and functional alterations in mitochondria (mt) and their metabolites have been implicated...

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Detalles Bibliográficos
Autores principales: SanGiovanni, John Paul, Arking, Dan E., Iyengar, Sudha K., Elashoff, Michael, Clemons, Traci E., Reed, George F., Henning, Alice K., Sivakumaran, Theru A., Xu, Xuming, DeWan, Andrew, Agrón, Elvira, Rochtchina, Elena, Sue, Carolyn M., Wang, Jie Jin, Mitchell, Paul, Hoh, Josephine, Francis, Peter J., Klein, Michael L., Chew, Emily Y., Chakravarti, Aravinda
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677106/
https://www.ncbi.nlm.nih.gov/pubmed/19434233
http://dx.doi.org/10.1371/journal.pone.0005508

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677106/
https://www.ncbi.nlm.nih.gov/pubmed/19434233
http://dx.doi.org/10.1371/journal.pone.0005508

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