Cargando…
Mitochondrial DNA Variants of Respiratory Complex I that Uniquely Characterize Haplogroup T2 Are Associated with Increased Risk of Age-Related Macular Degeneration
BACKGROUND: Age-related macular degeneration (AMD), a chronic neurodegenerative and neovascular retinal disease, is the leading cause of blindness in elderly people of western European origin. While structural and functional alterations in mitochondria (mt) and their metabolites have been implicated...
Autores principales: | SanGiovanni, John Paul, Arking, Dan E., Iyengar, Sudha K., Elashoff, Michael, Clemons, Traci E., Reed, George F., Henning, Alice K., Sivakumaran, Theru A., Xu, Xuming, DeWan, Andrew, Agrón, Elvira, Rochtchina, Elena, Sue, Carolyn M., Wang, Jie Jin, Mitchell, Paul, Hoh, Josephine, Francis, Peter J., Klein, Michael L., Chew, Emily Y., Chakravarti, Aravinda |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2009
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677106/ https://www.ncbi.nlm.nih.gov/pubmed/19434233 http://dx.doi.org/10.1371/journal.pone.0005508 |
Ejemplares similares
-
Small Drusen and Age-Related Macular Degeneration: The Beaver Dam Eye Study
por: Klein, Ronald, et al.
Publicado: (2015) -
Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration
por: Kopplin, Laura J, et al.
Publicado: (2010) -
DNA Sequence Variants in PPARGC1A, a Gene Encoding a Coactivator of the ω-3 LCPUFA Sensing PPAR-RXR Transcription Complex, Are Associated with NV AMD and AMD-Associated Loci in Genes of Complement and VEGF Signaling Pathways
por: SanGiovanni, John Paul, et al.
Publicado: (2013) -
Validation and extension of an empirical Bayes method for SNP calling on Affymetrix microarrays
por: Lin, Shin, et al.
Publicado: (2008) -
Functional Differences between Mitochondrial Haplogroup T and Haplogroup H in HEK293 Cybrid Cells
por: Mueller, Edith E., et al.
Publicado: (2012)