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Functional Analysis of a Dominant Negative Mutation of Interferon Regulatory Factor 5

BACKGROUND: Interferon regulatory factor (IRF) family members have been implicated as critical transcription factors that function in immune response, hematopoietic differentiation and cell growth regulation. Activation of IRF-5 results in the production of pro-inflammatory cytokines such as TNFα, I...

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Detalles Bibliográficos
Autores principales: Yang, Long, Zhao, Tiejun, Shi, Xiaoliu, Nakhaei, Peyman, Wang, Yunling, Sun, Qiang, Hiscott, John, Lin, Rongtuan
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677155/
https://www.ncbi.nlm.nih.gov/pubmed/19430534
http://dx.doi.org/10.1371/journal.pone.0005500