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Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon
Induced pluripotent stem cells (iPSCs) have been generated from somatic cells by transgenic expression of Oct4, Sox2, Klf4, and cMyc. A major difficulty in the application of this technology for regenerative medicine, however, is the delivery of reprogramming factors. Whereas retroviral transduction...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677165/ https://www.ncbi.nlm.nih.gov/pubmed/19337237 http://dx.doi.org/10.1038/nmeth.1323 |