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Two distinct signalling cascades target the NF-κB regulatory factor c-IAP1 for degradation
c-IAP1 (cellular inhibitor of apoptosis 1) has recently emerged as a negative regulator of the non-canonical NF-κB (nuclear factor κB) signalling cascade. Whereas synthetic IAP inhibitors have been shown to trigger the autoubiquitination and degradation of c-IAP1, less is known about the physiologic...
Autores principales: | Csomos, Rebecca A., Wright, Casey W., Galbán, Stefanie, Oetjen, Karolyn A., Duckett, Colin S. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677214/ https://www.ncbi.nlm.nih.gov/pubmed/19243308 http://dx.doi.org/10.1042/BJ20082140 |
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