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Regulation of ErbB2 Receptor Status by the Proteasomal DUB POH1

Understanding the factors, which control ErbB2 and EGF receptor (EGFR) status in cells is likely to inform future therapeutic approaches directed at these potent oncogenes. ErbB2 is resistant to stimulus-induced degradation and high levels of over-expression can inhibit EGF receptor down-regulation....

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Detalles Bibliográficos
Autores principales: Liu, Han, Buus, Richard, Clague, Michael J., Urbé, Sylvie
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677670/
https://www.ncbi.nlm.nih.gov/pubmed/19436748
http://dx.doi.org/10.1371/journal.pone.0005544