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DNA damage induced p53 downregulates Cdc20 by direct binding to its promoter causing chromatin remodeling
CDC20 is a critical molecule in the Spindle Assembly Checkpoint (SAC). It activates the Anaphase promoting complex and helps a dividing cell to proceed towards Anaphase. CDC20 is overexpressed in many tumor cells which cause chromosomal instability. There have been limited reports on the mechanism o...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677870/ https://www.ncbi.nlm.nih.gov/pubmed/19273532 http://dx.doi.org/10.1093/nar/gkp110 |