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Transcript length bias in RNA-seq data confounds systems biology

BACKGROUND: Several recent studies have demonstrated the effectiveness of deep sequencing for transcriptome analysis (RNA-seq) in mammals. As RNA-seq becomes more affordable, whole genome transcriptional profiling is likely to become the platform of choice for species with good genomic sequences. As...

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Detalles Bibliográficos
Autores principales: Oshlack, Alicia, Wakefield, Matthew J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678084/
https://www.ncbi.nlm.nih.gov/pubmed/19371405
http://dx.doi.org/10.1186/1745-6150-4-14