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A human polymorphism affects NEDD4L subcellular targeting by leading to two isoforms that contain or lack a C2 domain

BACKGROUND: Ubiquitination serves multiple cellular functions, including proteasomal degradation and the control of stability, function, and intracellular localization of a wide variety of proteins. NEDD4L is a member of the HECT class of E3 ubiquitin ligases. A defining feature of NEDD4L protein is...

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Detalles Bibliográficos
Autores principales:	Garrone, Nicholas F, Blazer-Yost, Bonnie L, Weiss, Robert B, Lalouel, Jean-Marc, Rohrwasser, Andreas
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678989/ https://www.ncbi.nlm.nih.gov/pubmed/19364400 http://dx.doi.org/10.1186/1471-2121-10-26

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