Dpr Acts as a Molecular Switch, Inhibiting Wnt Signaling when Unphosphorylated, but Promoting Wnt Signaling when Phosphorylated by Casein Kinase Iδ/ε

The Wnt pathway is a key regulator of development and tumorigenesis. Dpr (Dact/Frodo) influences Wnt signaling in part through the interaction of its PDZ-B domain with Dsh's PDZ domain. Studies have shown that XDpr1a and its close relative, Frodo, are involved in multiple steps of the Wnt pathw...

Descripción completa

Detalles Bibliográficos
Autores principales: Teran, Evelyn, Branscomb, Aron D., Seeling, Joni M.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679210/
https://www.ncbi.nlm.nih.gov/pubmed/19440376
http://dx.doi.org/10.1371/journal.pone.0005522

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679210/
https://www.ncbi.nlm.nih.gov/pubmed/19440376
http://dx.doi.org/10.1371/journal.pone.0005522

Ejemplares similares