Identification of Loss of Function Mutations in Human Genes Encoding RIG-I and MDA5: IMPLICATIONS FOR RESISTANCE TO TYPE I DIABETES

Retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5) are essential for detecting viral RNA and triggering antiviral responses, including production of type I interferon. We analyzed the phenotype of non-synonymous mutants of human RIG-I and MDA5 reported in da...

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Detalles Bibliográficos
Autores principales: Shigemoto, Taeko, Kageyama, Maiko, Hirai, Reiko, Zheng, JiPing, Yoneyama, Mitsutoshi, Fujita, Takashi
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2009
Materias:
Mechanisms of Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679434/
https://www.ncbi.nlm.nih.gov/pubmed/19324880
http://dx.doi.org/10.1074/jbc.M809449200

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679434/
https://www.ncbi.nlm.nih.gov/pubmed/19324880
http://dx.doi.org/10.1074/jbc.M809449200

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