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Identification of Loss of Function Mutations in Human Genes Encoding RIG-I and MDA5: IMPLICATIONS FOR RESISTANCE TO TYPE I DIABETES

Retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5) are essential for detecting viral RNA and triggering antiviral responses, including production of type I interferon. We analyzed the phenotype of non-synonymous mutants of human RIG-I and MDA5 reported in da...

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Detalles Bibliográficos
Autores principales:	Shigemoto, Taeko, Kageyama, Maiko, Hirai, Reiko, Zheng, JiPing, Yoneyama, Mitsutoshi, Fujita, Takashi
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2009
Materias:	Mechanisms of Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679434/ https://www.ncbi.nlm.nih.gov/pubmed/19324880 http://dx.doi.org/10.1074/jbc.M809449200

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