Cargando…

Oxidative and Excitatory Mechanisms of Developmental Neurotoxicity: Transcriptional Profiles for Chlorpyrifos, Diazinon, Dieldrin, and Divalent Nickel in PC12 Cells

BACKGROUND: Oxidative stress and excitotoxicity underlie the developmental neurotoxicity of numerous chemicals. OBJECTIVES: We compared the effects of organophosphates (chlorpyrifos and diazinon), an organo-chlorine (dieldrin), and a metal [divalent nickel (Ni(2+))] to determine how these mechanisms...

Descripción completa

Detalles Bibliográficos
Autores principales:	Slotkin, Theodore A., Seidler, Frederic J.
Formato:	Texto
Lenguaje:	English
Publicado:	National Institute of Environmental Health Sciences 2009
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679603/ https://www.ncbi.nlm.nih.gov/pubmed/19440498 http://dx.doi.org/10.1289/ehp.0800251

Ejemplares similares

Nonenzymatic Functions of Acetylcholinesterase Splice Variants in the Developmental Neurotoxicity of Organophosphates: Chlorpyrifos, Chlorpyrifos Oxon, and Diazinon
por: Jameson, Ruth R., et al.
Publicado: (2007)

Ultraviolet Photolysis of Chlorpyrifos: Developmental Neurotoxicity Modeled in PC12 Cells
por: Slotkin, Theodore A., et al.
Publicado: (2009)

Screening for Developmental Neurotoxicity Using PC12 Cells: Comparisons of Organophosphates with a Carbamate, an Organochlorine, and Divalent Nickel
por: Slotkin, Theodore A., et al.
Publicado: (2007)

Ameliorating the Developmental Neurotoxicity of Chlorpyrifos: A Mechanisms-Based Approach in PC12 Cells
por: Slotkin, Theodore A., et al.
Publicado: (2007)

Developmental neurotoxicity of chlorpyrifos: what is the vulnerable period?
por: Qiao, Dan, et al.
Publicado: (2002)

An invertebrate model of the developmental neurotoxicity of insecticides: effects of chlorpyrifos and dieldrin in sea urchin embryos and larvae.
por: Buznikov, G A, et al.
Publicado: (2001)

Developmental neurotoxicity of chlorpyrifos modeled in vitro: comparative effects of metabolites and other cholinesterase inhibitors on DNA synthesis in PC12 and C6 cells.
por: Qiao, D, et al.
Publicado: (2001)

Developmental neurotoxicity elicited by gestational exposure to chlorpyrifos: when is adenylyl cyclase a target?
por: Meyer, Armando, et al.
Publicado: (2003)

Developmental neurotoxicity elicited by prenatal or postnatal chlorpyrifos exposure: effects on neurospecific proteins indicate changing vulnerabilities.
por: Garcia, Stephanie J, et al.
Publicado: (2003)

Developmental effects of chlorpyrifos extend beyond neurotoxicity: critical periods for immediate and delayed-onset effects on cardiac and hepatic cell signaling.
por: Meyer, Armando, et al.
Publicado: (2004)

Exposure to Organophosphates Reduces the Expression of Neurotrophic Factors in Neonatal Rat Brain Regions: Similarities and Differences in the Effects of Chlorpyrifos and Diazinon on the Fibroblast Growth Factor Superfamily
por: Slotkin, Theodore A., et al.
Publicado: (2007)

Adverse Benzo[a]pyrene Effects on Neurodifferentiation Are Altered by Other Neurotoxicant Coexposures: Interactions with Dexamethasone, Chlorpyrifos, or Nicotine in PC12 Cells
por: Slotkin, Theodore A., et al.
Publicado: (2013)

Chlorpyrifos Affects Phenotypic Outcomes in a Model of Mammalian Neurodevelopment: Critical Stages Targeting Differentiation in PC12 Cells
por: Jameson, Ruth R., et al.
Publicado: (2006)

Developmental Exposure of Rats to Chlorpyrifos Elicits Sex-Selective Hyperlipidemia and Hyperinsulinemia in Adulthood
por: Slotkin, Theodore A., et al.
Publicado: (2005)

Critical periods for chlorpyrifos-induced developmental neurotoxicity: alterations in adenylyl cyclase signaling in adult rat brain regions after gestational or neonatal exposure.
por: Meyer, Armando, et al.
Publicado: (2004)

Neonatal Organophosphorus Pesticide Exposure Alters the Developmental Trajectory of Cell-Signaling Cascades Controlling Metabolism: Differential Effects of Diazinon and Parathion
por: Adigun, Abayomi A., et al.
Publicado: (2010)

Serotonergic systems targeted by developmental exposure to chlorpyrifos: effects during different critical periods.
por: Aldridge, Justin E, et al.
Publicado: (2003)

Developmental cholinotoxicants: nicotine and chlorpyrifos.
por: Slotkin, T A
Publicado: (1999)

Developmental Exposure of Rats to Chlorpyrifos Leads to Behavioral Alterations in Adulthood, Involving Serotonergic Mechanisms and Resembling Animal Models of Depression
por: Aldridge, Justin E., et al.
Publicado: (2005)

Developmental Neurotoxicity of Perfluorinated Chemicals Modeled in Vitro
por: Slotkin, Theodore A., et al.
Publicado: (2008)

Comparative Developmental Neurotoxicity of Organophosphate Insecticides: Effects on Brain Development Are Separable from Systemic Toxicity
por: Slotkin, Theodore A., et al.
Publicado: (2006)

Neonatal Exposure to Low Doses of Diazinon: Long-Term Effects on Neural Cell Development and Acetylcholine Systems
por: Slotkin, Theodore A., et al.
Publicado: (2008)

Developmental exposure to chlorpyrifos elicits sex-selective alterations of serotonergic synaptic function in adulthood: critical periods and regional selectivity for effects on the serotonin transporter, receptor subtypes, and cell signaling.
por: Aldridge, Justin E, et al.
Publicado: (2004)

Safety of Safety Evaluation of Pesticides: developmental neurotoxicity of chlorpyrifos and chlorpyrifos-methyl
por: Mie, Axel, et al.
Publicado: (2018)

Silver Impairs Neurodevelopment: Studies in PC12 Cells
por: Powers, Christina M., et al.
Publicado: (2010)

Alterations in Central Nervous System Serotonergic and Dopaminergic Synaptic Activity in Adulthood after Prenatal or Neonatal Chlorpyrifos Exposure
por: Aldridge, Justin E., et al.
Publicado: (2005)

Organophosphate Insecticides Target the Serotonergic System in Developing Rat Brain Regions: Disparate Effects of Diazinon and Parathion at Doses Spanning the Threshold for Cholinesterase Inhibition
por: Slotkin, Theodore A., et al.
Publicado: (2006)

Fetal chlorpyrifos exposure: adverse effects on brain cell development and cholinergic biomarkers emerge postnatally and continue into adolescence and adulthood.
por: Qiao, Dan, et al.
Publicado: (2003)

Silver Nanoparticles Compromise Neurodevelopment in PC12 Cells: Critical Contributions of Silver Ion, Particle Size, Coating, and Composition
por: Powers, Christina M., et al.
Publicado: (2011)

Genome-Wide Gene Expression Analysis in Response to Organophosphorus Pesticide Chlorpyrifos and Diazinon in C. elegans
por: Viñuela, Ana, et al.
Publicado: (2010)

The sea urchin embryo as a model for mammalian developmental neurotoxicity: ontogenesis of the high-affinity choline transporter and its role in cholinergic trophic activity.
por: Qiao, Dan, et al.
Publicado: (2003)

Optimization of extraction conditions and determination of the Chlorpyrifos, Diazinon, and malathion residues in environment samples: Fruit (Apple, Orange, and Tomato)
por: Kashi, Giti, et al.
Publicado: (2021)

Letter to the editor regarding “safety of safety evaluation of pesticides: developmental neurotoxicity of chlorpyrifos and chlorpyrifos-methyl” by Mie et al. (environmental health. 2018. 17:77)
por: Juberg, Daland R., et al.
Publicado: (2019)

Correction to: Letter to the editor regarding “safety of safety evaluation of pesticides: developmental neurotoxicity of chlorpyrifos and chlorpyrifos-methyl” by Mie et al. (environmental health. 2018. 17:77)
por: Juberg, Daland R., et al.
Publicado: (2019)

Developmental and Lactational Exposure to Dieldrin Alters Mammary Tumorigenesis in Her2/neu Transgenic Mice
por: Cameron, Heather L., et al.
Publicado: (2009)

Effects of Nickel, Chlorpyrifos and Their Mixture on the Dictyostelium discoideum Proteome
por: Boatti, Lara, et al.
Publicado: (2012)

Induction of neurotoxicity by organophosphate pesticide chlorpyrifos and modulating role of cow urine
por: Sharma, Shelly, et al.
Publicado: (2016)

Molecular Evidence on the Inhibitory Potential of Metformin against Chlorpyrifos-Induced Neurotoxicity
por: Daniali, Marzieh, et al.
Publicado: (2022)

An Investigation of the Neurotoxic Effects of Malathion, Chlorpyrifos, and Paraquat to Different Brain Regions
por: Elmorsy, Ekramy, et al.
Publicado: (2022)

Suppression of MHV3 virus-activated macrophages by dieldrin
por: Krzystyniak, Krzysztof, et al.
Publicado: (1986)

Cannot write session to /tmp/vufind_sessions/sess_acc04gf5v0h3econtvqvmma6o2