Distinct roles for Foxo1 at multiple stages of B cell differentiation

The Foxo transcription factors (Foxo1, Foxo3, Foxo4) modulate cell fate decisions in diverse systems. Here we show that Foxo1-dependent gene expression was critical at multiple stages of B cell differentiation. Early deletion of Foxo1 caused a severe block at the pro-B cell stage, due to a failure t...

Descripción completa

Detalles Bibliográficos
Autores principales: Dengler, Hart S., Baracho, Gisele V., Omori, Sidne A., Bruckner, Shane, Arden, Karen, Castrillon, Diego H., DePinho, Ronald A., Rickert, Robert C.
Formato: Texto
Lenguaje:English
Publicado: 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679692/
https://www.ncbi.nlm.nih.gov/pubmed/18978794
http://dx.doi.org/10.1038/ni.1667

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679692/
https://www.ncbi.nlm.nih.gov/pubmed/18978794
http://dx.doi.org/10.1038/ni.1667

Ejemplares similares