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Genotyping and inflated type I error rate in genome-wide association case/control studies

BACKGROUND: One common goal of a case/control genome wide association study (GWAS) is to find SNPs associated with a disease. Traditionally, the first step in such studies is to assign a genotype to each SNP in each subject, based on a statistic summarizing fluorescence measurements. When the distri...

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Detalles Bibliográficos
Autores principales: Sampson, Joshua N, Zhao, Hongyu
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679732/
https://www.ncbi.nlm.nih.gov/pubmed/19236714
http://dx.doi.org/10.1186/1471-2105-10-68