IL-15 independent maintenance of virus-specific CD8(+) T cells in the CNS during chronic infection

The role of IL-15 in T cell survival was examined during chronic CNS coronavirus infection. Similar numbers of virus-specific CD8(+) T cells were retained in the CNS of IL-15(−/−) and wt mice, consistent with loss of IL-2/15 receptor (CD122) expression. IL-15 deficiency also had no affect on IL-7 re...

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Detalles Bibliográficos
Autores principales: Zuo, Jun, Stohlman, Stephen A., Parra, Gabriel I., Bergmann, Cornelia C.
Formato: Texto
Lenguaje:English
Publicado: Elsevier B.V. 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679951/
https://www.ncbi.nlm.nih.gov/pubmed/19106006
http://dx.doi.org/10.1016/j.jneuroim.2008.11.005
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author Zuo, Jun
Stohlman, Stephen A.
Parra, Gabriel I.
Bergmann, Cornelia C.
author_facet Zuo, Jun
Stohlman, Stephen A.
Parra, Gabriel I.
Bergmann, Cornelia C.
author_sort Zuo, Jun
collection PubMed
description The role of IL-15 in T cell survival was examined during chronic CNS coronavirus infection. Similar numbers of virus-specific CD8(+) T cells were retained in the CNS of IL-15(−/−) and wt mice, consistent with loss of IL-2/15 receptor (CD122) expression. IL-15 deficiency also had no affect on IL-7 receptor (CD127) expression, Bcl-2 upregulation, granzyme B expression, or IFN-γ secretion in CNS persisting CD8(+) T cells. Furthermore, CD8(+) T cell division in the CNS was reduced compared to spleen. CD8(+) T cells in the persistently infected CNS are thus characterized by IL-15 independent, low level proliferation and an activated/memory phenotype.
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spelling pubmed-26799512010-02-15 IL-15 independent maintenance of virus-specific CD8(+) T cells in the CNS during chronic infection Zuo, Jun Stohlman, Stephen A. Parra, Gabriel I. Bergmann, Cornelia C. J Neuroimmunol Article The role of IL-15 in T cell survival was examined during chronic CNS coronavirus infection. Similar numbers of virus-specific CD8(+) T cells were retained in the CNS of IL-15(−/−) and wt mice, consistent with loss of IL-2/15 receptor (CD122) expression. IL-15 deficiency also had no affect on IL-7 receptor (CD127) expression, Bcl-2 upregulation, granzyme B expression, or IFN-γ secretion in CNS persisting CD8(+) T cells. Furthermore, CD8(+) T cell division in the CNS was reduced compared to spleen. CD8(+) T cells in the persistently infected CNS are thus characterized by IL-15 independent, low level proliferation and an activated/memory phenotype. Elsevier B.V. 2009-02-15 2008-12-23 /pmc/articles/PMC2679951/ /pubmed/19106006 http://dx.doi.org/10.1016/j.jneuroim.2008.11.005 Text en Copyright © 2008 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Zuo, Jun
Stohlman, Stephen A.
Parra, Gabriel I.
Bergmann, Cornelia C.
IL-15 independent maintenance of virus-specific CD8(+) T cells in the CNS during chronic infection
title IL-15 independent maintenance of virus-specific CD8(+) T cells in the CNS during chronic infection
title_full IL-15 independent maintenance of virus-specific CD8(+) T cells in the CNS during chronic infection
title_fullStr IL-15 independent maintenance of virus-specific CD8(+) T cells in the CNS during chronic infection
title_full_unstemmed IL-15 independent maintenance of virus-specific CD8(+) T cells in the CNS during chronic infection
title_short IL-15 independent maintenance of virus-specific CD8(+) T cells in the CNS during chronic infection
title_sort il-15 independent maintenance of virus-specific cd8(+) t cells in the cns during chronic infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679951/
https://www.ncbi.nlm.nih.gov/pubmed/19106006
http://dx.doi.org/10.1016/j.jneuroim.2008.11.005
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