Expression of a Mutant p53 Results in an Age-Related Demographic Shift in Spontaneous Lung Tumor Formation in Transgenic Mice

BACKGROUND: Mutations in the P53 gene are among the most common genetic abnormalities in human lung cancer. Codon 273 in the sequence-specific DNA binding domain is one of the most frequently mutated sites. METHODOLOGY: To investigate the role of mutant p53 in lung tumorigenesis, a lung specific p53...

Descripción completa

Detalles Bibliográficos
Autores principales: Duan, Wenrui, Gao, Li, Wu, Xin, Hade, Erinn M., Gao, Jian-Xin, Ding, Haiming, Barsky, Sanford H., Otterson, Gregory A., Villalona-Calero, Miguel A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680060/
https://www.ncbi.nlm.nih.gov/pubmed/19440353
http://dx.doi.org/10.1371/journal.pone.0005563

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680060/
https://www.ncbi.nlm.nih.gov/pubmed/19440353
http://dx.doi.org/10.1371/journal.pone.0005563

Ejemplares similares