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Akirins, highly conserved nuclear proteins, required for NF-κB dependent gene expression in Drosophila and mice
During a genome-wide RNAi screen, we isolated CG8580 as a gene involved in the innate immune response of Drosophila. CG8580, which we named Akirin, acts in parallel with the NF-κB transcription factor downstream of the Imd pathway and was required for defense against Gram-negative bacteria. Akirin i...
Autores principales: | , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680477/ https://www.ncbi.nlm.nih.gov/pubmed/18066067 http://dx.doi.org/10.1038/ni1543 |