Polycomb Mediated Epigenetic Silencing and Replication Timing at the INK4a/ARF Locus during Senescence

BACKGROUND: The INK4/ARF locus encodes three tumor suppressor genes (p15(Ink4b), Arf and p16(Ink4a)) and is frequently inactivated in a large number of human cancers. Mechanisms regulating INK4/ARF expression are not fully characterized. PRINCIPAL FINDINGS: Here we show that in young proliferating e...

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Detalles Bibliográficos
Autores principales: Agherbi, Hanane, Gaussmann-Wenger, Anne, Verthuy, Christophe, Chasson, Lionel, Serrano, Manuel, Djabali, Malek
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680618/
https://www.ncbi.nlm.nih.gov/pubmed/19462008
http://dx.doi.org/10.1371/journal.pone.0005622

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680618/
https://www.ncbi.nlm.nih.gov/pubmed/19462008
http://dx.doi.org/10.1371/journal.pone.0005622

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