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Polycomb Mediated Epigenetic Silencing and Replication Timing at the INK4a/ARF Locus during Senescence
BACKGROUND: The INK4/ARF locus encodes three tumor suppressor genes (p15(Ink4b), Arf and p16(Ink4a)) and is frequently inactivated in a large number of human cancers. Mechanisms regulating INK4/ARF expression are not fully characterized. PRINCIPAL FINDINGS: Here we show that in young proliferating e...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680618/ https://www.ncbi.nlm.nih.gov/pubmed/19462008 http://dx.doi.org/10.1371/journal.pone.0005622 |