PKCε Regulates Behavioral Sensitivity, Binding and Tolerance to the CB1 Receptor Agonist WIN55,212-2

The cannabinoid CB1 receptor (CB1) is one of the most abundant G protein-coupled receptors in the brain, but little is known about the mechanisms that modulate CB1 receptor signaling. Here we show that inhibition or null mutation of the epsilon isozyme of protein kinase C (PKCε) selectively enhances...

Descripción completa

Detalles Bibliográficos
Autores principales: Wallace, Melisa J., Newton, Philip M., McMahon, Thomas, Connolly, Jacklyn, Huibers, Anne, Whistler, Jennifer, Messing, Robert O.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680927/
https://www.ncbi.nlm.nih.gov/pubmed/19158669
http://dx.doi.org/10.1038/npp.2008.230

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680927/
https://www.ncbi.nlm.nih.gov/pubmed/19158669
http://dx.doi.org/10.1038/npp.2008.230

Ejemplares similares