Diminished Telomeric 3′ Overhangs Are Associated with Telomere Dysfunction in Hoyeraal-Hreidarsson Syndrome

BACKGROUND: Eukaryotic chromosomes end with telomeres, which in most organisms are composed of tandem DNA repeats associated with telomeric proteins. These DNA repeats are synthesized by the enzyme telomerase, whose activity in most human tissues is tightly regulated, leading to gradual telomere sho...

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Detalles Bibliográficos
Autores principales: Lamm, Noa, Ordan, Elly, Shponkin, Rotem, Richler, Carmelit, Aker, Memet, Tzfati, Yehuda
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680952/
https://www.ncbi.nlm.nih.gov/pubmed/19461895
http://dx.doi.org/10.1371/journal.pone.0005666

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680952/
https://www.ncbi.nlm.nih.gov/pubmed/19461895
http://dx.doi.org/10.1371/journal.pone.0005666

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