Absence of AKT1 Mutations in Glioblastoma

BACKGROUND: Oncogenic activation of the PI3K signalling pathway plays a pivotal role in the development of glioblastoma multiforme (GBM). A central node in PI3K downstream signalling is controlled by the serine-threonine kinase AKT1. A somatic mutation affecting residue E17 of the AKT1 gene has rece...

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Detalles Bibliográficos
Autores principales: Bleeker, Fonnet E., Lamba, Simona, Zanon, Carlo, van Tilborg, Angela A., Leenstra, Sieger, Troost, Dirk, Hulsebos, Theo, Vandertop, W. Peter, Bardelli, Alberto
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680963/
https://www.ncbi.nlm.nih.gov/pubmed/19461960
http://dx.doi.org/10.1371/journal.pone.0005638

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680963/
https://www.ncbi.nlm.nih.gov/pubmed/19461960
http://dx.doi.org/10.1371/journal.pone.0005638

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