Cargando…

Absence of AKT1 Mutations in Glioblastoma

BACKGROUND: Oncogenic activation of the PI3K signalling pathway plays a pivotal role in the development of glioblastoma multiforme (GBM). A central node in PI3K downstream signalling is controlled by the serine-threonine kinase AKT1. A somatic mutation affecting residue E17 of the AKT1 gene has rece...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bleeker, Fonnet E., Lamba, Simona, Zanon, Carlo, van Tilborg, Angela A., Leenstra, Sieger, Troost, Dirk, Hulsebos, Theo, Vandertop, W. Peter, Bardelli, Alberto
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680963/ https://www.ncbi.nlm.nih.gov/pubmed/19461960 http://dx.doi.org/10.1371/journal.pone.0005638

Ejemplares similares

Mutational profiling of kinases in glioblastoma
por: Bleeker, Fonnet E, et al.
Publicado: (2014)

Recent advances in the molecular understanding of glioblastoma
por: Bleeker, Fonnet E., et al.
Publicado: (2012)

The prognostic IDH1(R132) mutation is associated with reduced NADP(+)-dependent IDH activity in glioblastoma
por: Bleeker, Fonnet E., et al.
Publicado: (2010)

Mutational Profile of GNAQ (Q209) in Human Tumors
por: Lamba, Simona, et al.
Publicado: (2009)

Advancements, Challenges, and Future Directions in Tackling Glioblastoma Resistance to Small Kinase Inhibitors
por: Fabro, Federica, et al.
Publicado: (2022)

Allele loss on chromosomes 10 and 17p and epidermal growth factor receptor gene amplification in human malignant astrocytoma related to prognosis.
por: Leenstra, S., et al.
Publicado: (1994)

Drug Repurposing, a Fast-Track Approach to Develop Effective Treatments for Glioblastoma
por: Ntafoulis, Ioannis, et al.
Publicado: (2022)

Multiomics profiling of paired primary and recurrent glioblastoma patient tissues
por: Dekker, Lennard J M, et al.
Publicado: (2020)

Effects of the IDH1 R132H Mutation on the Energy Metabolism: A Comparison between Tissue and Corresponding Primary Glioma Cell Cultures
por: Dekker, Lennard J. M., et al.
Publicado: (2022)

Novel kinome profiling technology reveals drug treatment is patient and 2D/3D model dependent in glioblastoma
por: Fabro, Federica, et al.
Publicado: (2022)

The analysis of PIK3CA mutations in gastric carcinoma and metanalysis of literature suggest that exon-selectivity is a signature of cancer type
por: Barbi, Stefano, et al.
Publicado: (2010)

Somatic mosaicism by a de novo MLH1 mutation as a cause of Lynch syndrome
por: Geurts‐Giele, Willemina R., et al.
Publicado: (2019)

A Zebrafish Live Imaging Model Reveals Differential Responses of Microglia Toward Glioblastoma Cells In Vivo
por: Hamilton, Lloyd, et al.
Publicado: (2016)

A modified fluctuation-test framework characterizes the population dynamics and mutation rate of colorectal cancer persister cells
por: Russo, Mariangela, et al.
Publicado: (2022)

Wasl is crucial to maintain microglial core activities during glioblastoma initiation stages
por: Mazzolini, Julie, et al.
Publicado: (2022)

Glioblastoma motility occurs in the absence of actin polymer
por: Panopoulos, Andreas, et al.
Publicado: (2011)

The HDAC Inhibitors Scriptaid and LBH589 Combined with the Oncolytic Virus Delta24-RGD Exert Enhanced Anti-Tumor Efficacy in Patient-Derived Glioblastoma Cells
por: Berghauser Pont, Lotte M.E., et al.
Publicado: (2015)

The Bcl-2 inhibitor Obatoclax overcomes resistance to histone deacetylase inhibitors SAHA and LBH589 as radiosensitizers in patient-derived glioblastoma stem-like cells
por: Berghauser Pont, Lotte M.E., et al.
Publicado: (2014)

TP53 mutated glioblastoma stem-like cell cultures are sensitive to dual mTORC1/2 inhibition while resistance in TP53 wild type cultures can be overcome by combined inhibition of mTORC1/2 and Bcl-2
por: Venkatesan, Subramanian, et al.
Publicado: (2016)

Information exchange between patients with Lynch syndrome and their genetic and non-genetic health professionals: whose responsibility?
por: Douma, Kirsten F. L., et al.
Publicado: (2018)

Reliance upon ancestral mutations is maintained in colorectal cancers that heterogeneously evolve during targeted therapies
por: Russo, Mariangela, et al.
Publicado: (2018)

The In Vivo Therapeutic Efficacy of the Oncolytic Adenovirus Delta24-RGD Is Mediated by Tumor-Specific Immunity
por: Kleijn, Anne, et al.
Publicado: (2014)

Work of Breathing into Snow in the Presence versus Absence of an Artificial Air Pocket Affects Hypoxia and Hypercapnia of a Victim Covered with Avalanche Snow: A Randomized Double Blind Crossover Study
por: Roubík, Karel, et al.
Publicado: (2015)

Identifying the BRCA1 c.-107A > T variant in Dutch patients with a tumor BRCA1 promoter hypermethylation
por: de Jong, Vincent M. T., et al.
Publicado: (2022)

AKT/GSK3β Signaling in Glioblastoma
por: Majewska, Ewelina, et al.
Publicado: (2016)

Absence of a sexual dimorphism in postprandial glucose metabolism after administration of a balanced mixed meal in healthy young volunteers
por: Leone, Alessandro, et al.
Publicado: (2022)

ABT-888 enhances cytotoxic effects of temozolomide independent of MGMT status in serum free cultured glioma cells
por: Balvers, Rutger K, et al.
Publicado: (2015)

Prediction of transient tumor enlargement using MRI tumor texture after radiosurgery on vestibular schwannoma
por: Langenhuizen, Patrick P. J. H., et al.
Publicado: (2020)

Akt and mTORC1 signaling as predictive biomarkers for the EGFR antibody nimotuzumab in glioblastoma
por: Ronellenfitsch, Michael W., et al.
Publicado: (2018)

Identification of Novel Candidate Oncogenes in Chromosome Region 17p11.2-p12 in Human Osteosarcoma
por: Both, Joeri, et al.
Publicado: (2012)

Spinal motoneuron synaptic plasticity after axotomy in the absence of inducible nitric oxide synthase
por: Emirandetti, Amanda, et al.
Publicado: (2010)

Gamma knife radiosurgery for recurrent gliomas
por: Sadik, Zjiwar H. A., et al.
Publicado: (2018)

Genomic Exploration of Distinct Molecular Phenotypes Steering Temozolomide Resistance Development in Patient-Derived Glioblastoma Cells
por: Fabro, Federica, et al.
Publicado: (2023)

Daunorubicin and doxorubicin but not BCNU have deleterious effects on organotypic multicellular spheroids of gliomas.
por: Kaaijk, P., et al.
Publicado: (1996)

Combined inhibition of AKT/mTOR and MDM2 enhances Glioblastoma Multiforme cell apoptosis and differentiation of cancer stem cells
por: Daniele, Simona, et al.
Publicado: (2015)

Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1
por: Lu, Mingjian, et al.
Publicado: (2012)

Absence of NR2E1 mutations in patients with aniridia
por: Corso-Díaz, Ximena, et al.
Publicado: (2012)

AKT Pathway Genes Define 5 Prognostic Subgroups in Glioblastoma
por: Joy, Anna, et al.
Publicado: (2014)

Dual VEGFA/BRAF targeting boosts PD‐1 blockade in melanoma through GM‐CSF‐mediated infiltration of M1 macrophages
por: Comunanza, Valentina, et al.
Publicado: (2023)

Secondary meningioma in a long-term survivor of atypical teratoid/rhabdoid tumour with a germline INI1 mutation
por: Ammerlaan, A. C. J., et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_quk4a6id8n1qb5mvhbpp793cfj