Differential regulation of RhoA-mediated signaling by the TPα and TPβ isoforms of the human thromboxane A2 receptor: Independent modulation of TPα signaling by prostacyclin and nitric oxide

In humans, thromboxane (TX) A(2) signals through the TPα and TPβ isoforms of the TXA(2) receptor that exhibit common and distinct roles. For example, Gq/phospholipase (PL)Cβ signaling by TPα is directly inhibited by the vasodilators prostacyclin and nitric oxide (NO) whereas that signaling by TPβ is...

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Detalles Bibliográficos
Autores principales: Wikström, Katarina, Kavanagh, David J., Reid, Helen M., Kinsella, B. Therese
Formato: Texto
Lenguaje:English
Publicado: Elsevier Science Ltd 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681257/
https://www.ncbi.nlm.nih.gov/pubmed/18502100
http://dx.doi.org/10.1016/j.cellsig.2008.04.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681257/
https://www.ncbi.nlm.nih.gov/pubmed/18502100
http://dx.doi.org/10.1016/j.cellsig.2008.04.006

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