Combination Therapy Using Chimeric Monoclonal Antibodies Protects Mice from Lethal H5N1 Infection and Prevents Formation of Escape Mutants

BACKGROUND: Given that there is a possibility of a human H5N1 pandemic and the fact that the recent H5N1 viruses are resistant to the anti-viral drugs, newer strategies for effective therapy are warranted. Previous studies show that single mAbs in immune prophylaxis can be protective against H5N1 in...

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Detalles Bibliográficos
Autores principales: Prabakaran, Mookkan, Prabhu, Nayana, He, Fang, Hongliang, Qian, Ho, Hui-Ting, Qiang, Jia, TaoMeng, Goutama, Michael, Kwang, Jimmy
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682562/
https://www.ncbi.nlm.nih.gov/pubmed/19478856
http://dx.doi.org/10.1371/journal.pone.0005672

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682562/
https://www.ncbi.nlm.nih.gov/pubmed/19478856
http://dx.doi.org/10.1371/journal.pone.0005672

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