Highly Active Microbial Phosphoantigen Induces Rapid yet Sustained MEK/Erk- and PI-3K/Akt-Mediated Signal Transduction in Anti-Tumor Human γδ T-Cells

BACKGROUND: The unique responsiveness of Vγ9Vδ2 T-cells, the major γδ subset of human peripheral blood, to non-peptidic prenyl pyrophosphate antigens constitutes the basis of current γδ T-cell-based cancer immunotherapy strategies. However, the molecular mechanisms responsible for phosphoantigen-med...

Descripción completa

Detalles Bibliográficos
Autores principales: Correia, Daniel V., d'Orey, Francisco, Cardoso, Bruno A., Lança, Telma, Grosso, Ana R., deBarros, Ana, Martins, Leila R., Barata, João T., Silva-Santos, Bruno
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682580/
https://www.ncbi.nlm.nih.gov/pubmed/19479075
http://dx.doi.org/10.1371/journal.pone.0005657

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682580/
https://www.ncbi.nlm.nih.gov/pubmed/19479075
http://dx.doi.org/10.1371/journal.pone.0005657

Ejemplares similares