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Highly Active Microbial Phosphoantigen Induces Rapid yet Sustained MEK/Erk- and PI-3K/Akt-Mediated Signal Transduction in Anti-Tumor Human γδ T-Cells

BACKGROUND: The unique responsiveness of Vγ9Vδ2 T-cells, the major γδ subset of human peripheral blood, to non-peptidic prenyl pyrophosphate antigens constitutes the basis of current γδ T-cell-based cancer immunotherapy strategies. However, the molecular mechanisms responsible for phosphoantigen-med...

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Detalles Bibliográficos
Autores principales:	Correia, Daniel V., d'Orey, Francisco, Cardoso, Bruno A., Lança, Telma, Grosso, Ana R., deBarros, Ana, Martins, Leila R., Barata, João T., Silva-Santos, Bruno
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682580/ https://www.ncbi.nlm.nih.gov/pubmed/19479075 http://dx.doi.org/10.1371/journal.pone.0005657

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