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Impact of Growth Hormone (GH) Deficiency and GH Replacement upon Thymus Function in Adult Patients

BACKGROUND: Despite age-related adipose involution, T cell generation in the thymus (thymopoiesis) is maintained beyond puberty in adults. In rodents, growth hormone (GH), insulin-like growth factor-1 (IGF-1), and GH secretagogues reverse age-related changes in thymus cytoarchitecture and increase t...

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Detalles Bibliográficos
Autores principales: Morrhaye, Gabriel, Kermani, Hamid, Legros, Jean-Jacques, Baron, Frederic, Beguin, Yves, Moutschen, Michel, Cheynier, Remi, Martens, Henri J., Geenen, Vincent
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682582/
https://www.ncbi.nlm.nih.gov/pubmed/19479077
http://dx.doi.org/10.1371/journal.pone.0005668