Inactivation of GSK-3β by Metallothionein Prevents Diabetes-Related Changes in Cardiac Energy Metabolism, Inflammation, Nitrosative Damage, and Remodeling

OBJECTIVE: Glycogen synthase kinase (GSK)-3β plays an important role in cardiomyopathies. Cardiac-specific metallothionein-overexpressing transgenic (MT-TG) mice were highly resistant to diabetes-induced cardiomyopathy. Therefore, we investigated whether metallothionein cardiac protection against di...

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Detalles Bibliográficos
Autores principales: Wang, Yuehui, Feng, Wenke, Xue, Wanli, Tan, Yi, Hein, David W., Li, Xiao-Kun, Cai, Lu
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682666/
https://www.ncbi.nlm.nih.gov/pubmed/19324938
http://dx.doi.org/10.2337/db08-1697

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682666/
https://www.ncbi.nlm.nih.gov/pubmed/19324938
http://dx.doi.org/10.2337/db08-1697

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