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Inactivation of GSK-3β by Metallothionein Prevents Diabetes-Related Changes in Cardiac Energy Metabolism, Inflammation, Nitrosative Damage, and Remodeling

OBJECTIVE: Glycogen synthase kinase (GSK)-3β plays an important role in cardiomyopathies. Cardiac-specific metallothionein-overexpressing transgenic (MT-TG) mice were highly resistant to diabetes-induced cardiomyopathy. Therefore, we investigated whether metallothionein cardiac protection against di...

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Detalles Bibliográficos
Autores principales:	Wang, Yuehui, Feng, Wenke, Xue, Wanli, Tan, Yi, Hein, David W., Li, Xiao-Kun, Cai, Lu
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2009
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682666/ https://www.ncbi.nlm.nih.gov/pubmed/19324938 http://dx.doi.org/10.2337/db08-1697

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