PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Interferon-γ–Induced Pancreatic β-Cell Apoptosis

OBJECTIVE: The pathogenesis of type 1 diabetes has a strong genetic component. Genome-wide association scans recently identified novel susceptibility genes including the phosphatases PTPN22 and PTPN2. We hypothesized that PTPN2 plays a direct role in β-cell demise and assessed PTPN2 expression in hu...

Descripción completa

Detalles Bibliográficos
Autores principales: Moore, Fabrice, Colli, Maikel L., Cnop, Miriam, Esteve, Mariana Igoillo, Cardozo, Alessandra K., Cunha, Daniel A., Bugliani, Marco, Marchetti, Piero, Eizirik, Décio L.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682688/
https://www.ncbi.nlm.nih.gov/pubmed/19336676
http://dx.doi.org/10.2337/db08-1510

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682688/
https://www.ncbi.nlm.nih.gov/pubmed/19336676
http://dx.doi.org/10.2337/db08-1510

Ejemplares similares