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Mice Deficient in Ribosomal Protein S6 Phosphorylation Suffer from Muscle Weakness that Reflects a Growth Defect and Energy Deficit

BACKGROUND: Mice, whose ribosomal protein S6 cannot be phosphorylated due to replacement of all five phosphorylatable serine residues by alanines (rpS6(P−/−)), are viable and fertile. However, phenotypic characterization of these mice and embryo fibroblasts derived from them, has established the rol...

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Detalles Bibliográficos
Autores principales: Ruvinsky, Igor, Katz, Maximiliano, Dreazen, Avigail, Gielchinsky, Yuval, Saada, Ann, Freedman, Nanette, Mishani, Eyal, Zimmerman, Gabriel, Kasir, Judith, Meyuhas, Oded
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682700/
https://www.ncbi.nlm.nih.gov/pubmed/19479038
http://dx.doi.org/10.1371/journal.pone.0005618