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A Correspondence Between Solution-State Dynamics of an Individual Protein and the Sequence and Conformational Diversity of its Family

Conformational ensembles are increasingly recognized as a useful representation to describe fundamental relationships between protein structure, dynamics and function. Here we present an ensemble of ubiquitin in solution that is created by sampling conformational space without experimental informati...

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Detalles Bibliográficos
Autores principales: Friedland, Gregory D., Lakomek, Nils-Alexander, Griesinger, Christian, Meiler, Jens, Kortemme, Tanja
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682763/
https://www.ncbi.nlm.nih.gov/pubmed/19478996
http://dx.doi.org/10.1371/journal.pcbi.1000393