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GSK-3β phosphorylation of functionally distinct tau isoforms has differential, but mild effects

BACKGROUND: Tau protein exists as six different isoforms that differ by the inclusion or exclusion of exons 2, 3 and 10. Exon 10 encodes a microtubule binding repeat, thereby resulting in three isoforms with three microtubule binding repeats (3R) and three isoforms that have four microtubule binding...

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Detalles Bibliográficos
Autores principales: Voss, Kellen, Gamblin, T Chris
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683827/
https://www.ncbi.nlm.nih.gov/pubmed/19409104
http://dx.doi.org/10.1186/1750-1326-4-18