In Vivo Generation of Neurotoxic Prion Protein: Role for Hsp70 in Accumulation of Misfolded Isoforms

Prion diseases are incurable neurodegenerative disorders in which the normal cellular prion protein (PrP(C)) converts into a misfolded isoform (PrP(Sc)) with unique biochemical and structural properties that correlate with disease. In humans, prion disorders, such as Creutzfeldt-Jakob disease, prese...

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Detalles Bibliográficos
Autores principales: Fernandez-Funez, Pedro, Casas-Tinto, Sergio, Zhang, Yan, Gómez-Velazquez, Melisa, Morales-Garza, Marco A., Cepeda-Nieto, Ana C., Castilla, Joaquín, Soto, Claudio, Rincon-Limas, Diego E.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683939/
https://www.ncbi.nlm.nih.gov/pubmed/19503596
http://dx.doi.org/10.1371/journal.pgen.1000507

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683939/
https://www.ncbi.nlm.nih.gov/pubmed/19503596
http://dx.doi.org/10.1371/journal.pgen.1000507

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