BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis

Regulation of BubR1 is central to the control of APC/C activity. We have found that BubR1 forms a complex with PCAF and is acetylated at lysine 250. Using mass spectrometry and acetylated BubR1-specific antibodies, we have confirmed that BubR1 acetylation occurs at prometaphase. Importantly, BubR1 a...

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Detalles Bibliográficos
Autores principales: Choi, Eunhee, Choe, Hyerim, Min, Jaewon, Choi, Ji Yoon, Kim, Jimi, Lee, Hyunsook
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684026/
https://www.ncbi.nlm.nih.gov/pubmed/19407811
http://dx.doi.org/10.1038/emboj.2009.123

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684026/
https://www.ncbi.nlm.nih.gov/pubmed/19407811
http://dx.doi.org/10.1038/emboj.2009.123

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