Neuroprotective Effects of the Triterpenoid, CDDO Methyl Amide, a Potent Inducer of Nrf2-Mediated Transcription

The NF-E2-related factor-2 (Nrf2)/antioxidant response element (ARE) signaling pathway regulates phase 2 detoxification genes, including a variety of antioxidative enzymes. We tested neuroprotective effects of the synthetic triterpenoid CDDO-MA, a potent activator of the Nrf2/ARE signaling. CDDO-MA...

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Detalles Bibliográficos
Autores principales: Yang, Lichuan, Calingasan, Noel Y., Thomas, Bobby, Chaturvedi, Rajnish K., Kiaei, Mahmoud, Wille, Elizabeth J., Liby, Karen T., Williams, Charlotte, Royce, Darlene, Risingsong, Renee, Musiek, Eric S., Morrow, Jason D., Sporn, Michael, Beal, M. Flint
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684590/
https://www.ncbi.nlm.nih.gov/pubmed/19484125
http://dx.doi.org/10.1371/journal.pone.0005757

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684590/
https://www.ncbi.nlm.nih.gov/pubmed/19484125
http://dx.doi.org/10.1371/journal.pone.0005757

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