Genetic Knock-Down of HDAC7 Does Not Ameliorate Disease Pathogenesis in the R6/2 Mouse Model of Huntington's Disease

Huntington's disease (HD) is an inherited, progressive neurological disorder caused by a CAG/polyglutamine repeat expansion, for which there is no effective disease modifying therapy. In recent years, transcriptional dysregulation has emerged as a pathogenic process that appears early in diseas...

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Detalles Bibliográficos
Autores principales: Benn, Caroline L., Butler, Rachel, Mariner, Lydia, Nixon, Jude, Moffitt, Hilary, Mielcarek, Michal, Woodman, Ben, Bates, Gillian P.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684627/
https://www.ncbi.nlm.nih.gov/pubmed/19484127
http://dx.doi.org/10.1371/journal.pone.0005747

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684627/
https://www.ncbi.nlm.nih.gov/pubmed/19484127
http://dx.doi.org/10.1371/journal.pone.0005747

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