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Genetic Knock-Down of HDAC7 Does Not Ameliorate Disease Pathogenesis in the R6/2 Mouse Model of Huntington's Disease
Huntington's disease (HD) is an inherited, progressive neurological disorder caused by a CAG/polyglutamine repeat expansion, for which there is no effective disease modifying therapy. In recent years, transcriptional dysregulation has emerged as a pathogenic process that appears early in diseas...
Autores principales: | Benn, Caroline L., Butler, Rachel, Mariner, Lydia, Nixon, Jude, Moffitt, Hilary, Mielcarek, Michal, Woodman, Ben, Bates, Gillian P. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684627/ https://www.ncbi.nlm.nih.gov/pubmed/19484127 http://dx.doi.org/10.1371/journal.pone.0005747 |
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